Monkey and Bryce investigate the evil General Kato. The trail leads to an underground casino, where Monkey embraces the human world while struggling to continue his mission.
After the Yakuza put a price on Monkey’s head, he and Bryce must face off against a who’s who of the city’s most colorful assassins, and their greatest foe of all: Bryce’s ego.
Ditching Bryce, Monkey returns to his old hot-springs and attempts to join a new tribe. Meanwhile, Bryce is forced to relive the events that thrust him down the path of assassin-hood.
A reunited Monkey and Bryce get some much needed help from a pair of unexpected friends. They head to their final target and discover a startling truth.
Monkey, Bryce, and Haruka break protocol, demanding to know who set them up. This leads them to a mysterious Member's Only club, where an unlikely assassin aids in their mission.
Monkey is violently reunited with Akiko, while the rift with Bryce deepens. Meanwhile, Monkey's bonds with the Co-Op grows deeper, and Boone's tragic past comes to light.
Monkey, Bryce, Haruka, and The Co-Op visit The Shepherd's ranch estate to retrieve the final relic, but he and his wife aren't going down without a fight.
Bryce, Haruka, and Iris turn Eunice's beach house into a fortress, awaiting the Co-Op's invasion. But when Monkey shows up, it triggers a knock-down, drag-out fight.
The Co-Op uses the reforged relic to unleash the full power of the natural world on New York City. It's up to our gang and a group of unlikely heroes to stop them from destroying all of humankind.
Monkey and Bryce fight Boone throughout history, and ultimately Monkey is forced to face his true origin. But just when they think they've won the day, Akiko returns to take revenge.